Richter c. 21.

Richter transformation with c-MYC overexpression: report of three cases.

Pathogenesis of Richter transformation (RT) or Richter syndrome (RS) of chronic lymphocytic leukemia (CLL) is still largely unknown. Increasing evidences show that c-MYC may play a role in the development of RS. Here we report three cases of RS with overexpression of c-MYC. The first case was a 78-year-old male who initially presented with CLL and then developed diffuse lymphadenopathy and asci...

Josef Richter

Wolfram F . Richter

The working papers published in the Series constitute work in progress circulated to stimulate discussion and critical comments. Views expressed represent exclusively the authors' own opinions and do not necessarily reflect those of the editors. Die Deutsche Nationalbibliothek verzeichnet diese Publikation in der Deutschen Nationalbibliografie; detaillierte bibliografische Daten sind im Interne...

Heather Richter

INTRODUCTION My research career began as an undergraduate in Software Engineering, exploring formal specification of functional models. My interest in the human aspects of software engineering led me to Human-Computer Interaction (HCI) and Ubiquitous Computing as a graduate student, where I have investigated automated meeting capture and access. I implemented and evaluated prototypes that captu...

How we treat Richter syndrome.

Richter syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). RS occurs in approximately 2% to 10% of CLL patients during the course of their disease, with a transformation rate of 0.5% to 1% per year. A combination of germline genetic characteristics, clinical features (eg, advanced...